Journal of Oral Medicine and Pain

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Fig. 1.

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Fig. 1. GDF11 deficiency, in contrast to MSTN deficiency, impairs calvarial bone formation. (A) Representative three-dimensional reconstructed micro-CT images of calvarial bones of newborn wt, Gdf11-/-, and Mstn-/- mice. Superior views are displayed, and color-coded images that represent bone thickness distribution are shown in the lower panel. Note the retarded ossification in Gdf11-/- mice. All scale bars are dis­played with actual size values. (B) Mor­phometric analysis of cranial bone volume, bone thickness, and tissue mineral density of newborn wt, Gdf11-/-, and Mstn-/- mice (n=4 mice each). GDF11, growth differentiation factor 11; MSTN, myostatin; Micro-CT, micro-computed tomography; wt, wild-type. All data re­present mean±standard error of the mean. *p<0.05, **p<0.01 by ANOVA with Tukey’s post hoc test.
J Oral Med Pain 2020;45:83-8 https://doi.org/10.14476/jomp.2020.45.4.83
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