Journal of Oral Medicine and Pain

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 2383-8493   pISSN 2288-9272

Fig. 2.

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Fig. 2. GDF11 deficiency impairs lower incisor formation. (A) Reconstructed micro-CT images of newborn mouse skull. The top and middle panels represent lateral and inferior views, respectively. The red boxed region in the top panel indicates the area displayed in (B). Magnified inferior view of the red boxed region in the middle panel is displayed in the bottom panel. The red and yellow lines indicate the midsagittal and parasagittal planes of the lower incisor, respectively. (B) Representative three-dimensional reconstructed micro-CT images of lower incisors of newborn wt, Gdf11-/-, and Mstn-/- mice. Color-coded images that represent tissue thickness distribution are shown in the lower panels. Note the reduced incisor length in Gdf11-/- mice. All scale bars are displayed with actual size values. (C) Morphometric analysis of lower incisor length, tissue volume, tissue thickness, and tissue mineral density of newborn wt, Gdf11-/-, and Mstn-/- mice (n=3 mice each). GDF11, growth differentiation factor 11; Micro-CT, micro-computed tomography; wt, wild-type; MSTN, myostatin. All data represent mean±standard error of the mean. *p<0.05 by ANOVA with Tukey’s post hoc test.
J Oral Med Pain 2020;45:83-8 https://doi.org/10.14476/jomp.2020.45.4.83
© 2020 J Oral Med Pain