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Ultrasound-guided Platelet-rich Plasma Prolotherapy for Temporomandibular Disorders
J Oral Med Pain 2014;39:140-145
Published online December 31, 2014
© 2014 Korean Academy of Orofacial Pain and Oral Medicine

Seong-Yong Moon1, Sun-Tae Lee2, Ji-Won Ryu3

1Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Gwangju, Korea 2Department of Oral and Maxillofacial Surgery, Chosun University Dental Hospital, Gwangju, Korea 3Department of Oral Medicine, School of Dentistry, Chosun University, Gwangju, Korea
Correspondence to:

Ji-Won Ryu

Department of Oral Medicine, School of Dentistry, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 501-759, Korea

Tel: +82-62-220-3897 Fax: +82-62-234-2119 E-mail:

Received September 5, 2014; Revised September 15, 2014; Accepted October 1, 2014.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: Temporomandibular disorder (TMD) is one of the most common diseases causing chronic orofacial pain. Prolotherapy is called ‘regenerative injection therapy’ or ‘growth factor stimulation injection’, and it induces the functional reactivation of tissues such as ligaments and tendons. The aim of this study is to evaluate the efficacy of ultrasound-guided prolotherapy with platelet-rich plasma (PRP) for the patients who had the TMD symptoms, especially in temporomandibular joint (TMJ) pain, restricted mouth opening, and TMJ sound.
Methods: Twenty-seven patients visited Chosun University Dental Hospital with the symptoms of pain, restricted mouth opening, and TMJ sound were included in this study. When the patients visited the hospital, we measured; the degree of pain, range of mouth opening (ROM), and TMJ sound, and grouped them according to their chief complaints. TMJ pain and ROM were measured both at the first visit and the fourth week after the PRP injection, and also evaluated the impact of the treatment on their daily activities.
Results: After the treatment, the patients in the TMJ pain group showed some improvement (visual analogue scale [VAS] 5.6 to 3.6), and the patients in the restricted mouth opening group exhibited increased ROM (26 mm to 32 mm; p<0.05). On the other hand, the patients in the TMJ sound group had no improvement.
Conclusions: PRP prolotherapy could be effective for the treatment of TMJ pain and restricted mouth opening. However, further studies are still necessary in terms of TMJ sound and longterm effect of PRP prolotherapy.
Keywords : Arthrocentesis; Platelet-rich plasma; Prolotherapy; Temporomandibular joint disorders; Ultrasonography

June 2018, 43 (2)