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Antidiuretic Hormone Levels in Men with Burning Mouth Syndrome: A Pilot Study
J Oral Med Pain 2017;42:116-124
Published online December 30, 2017
© 2017 Korean Academy of Orofacial Pain and Oral Medicine

Yeon-Hee Lee1, Mi-Jin Hwang1, Suk Chon2, Q-Schick Auh1

1Department of Orofacial Pain and Oral Medicine, Kyung Hee University Dental Hospital, Seoul, Korea
2Department of Endocrinology and Metabolism, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea
Correspondence to: Yeon-Hee Lee
Department of Orofacial Pain and Oral Medicine, Kyung Hee University Dental Hospital, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
Tel: +82-2-958-9454
Fax: +82-2-962-8124
Received October 14, 2017; Revised November 15, 2017; Accepted November 17, 2017.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: Burning mouth syndrome (BMS) is a disabling pain that mostly occurs in elderly women, but rarely in men. It is characterized by an unremitting oral burning sensation and pain without detectable oral mucosal changes. We investigated the clinical and hematologic features of middle-aged men with BMS, and compared the results to those of men with oral mucositis.
Methods: Five men with BMS (48.60±6.19 years) and five age-matched controls with oral mucositis (49.80±15.26 years) underwent clinical and psychological evaluations and blood tests. Psychological status was evaluated using the Symptom Checklist-90-Revised. Cortisol, estradiol, progesterone, testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), adrenocorticotropic hormone (ACTH), and antidiuretic hormone (ADH) levels and erythrocyte sedimentation rate (ESR) were determined from the blood samples.
Results: ADH level was significantly lower in men with BMS than in the controls. ADH levels correlated with testosterone (p〈0.01), and ACTH levels strongly correlated with ESR (p〈0.05). Progesterone level positively correlated with FSH and LH levels. Pain intensity on a visual analogue scale correlated with estradiol level only in men with BMS. Among psychological factors, the obsessive-compulsive disorder, interpersonal-sensitivity, and anxiety scores were higher in men with BMS than in the controls (p〈0.05). However, no correlations were observed between the psychological and hematologic factors in both groups. The BMS symptoms presented only on the tongue, with the lateral border being the most prevalent area.
Conclusions: Men with BMS may experience dysregulated endocrinologic or psychoneuroendocrinologic interactions, which might affect oral BMS symptoms, aggravating the severity of the burning sensation.
Keywords : Antidiuretic hormone; Blood; Burning mouth syndrome; Estradiol; Gonadal hormone; Male

December 2018, 43 (4)