search for


Clinical and Hematologic Characteristics of Temporomandibular Disorders Patients
J Oral Med Pain 2018;43:41-51
Published online June 30, 2018;
© 2018 Korean Academy of Orofacial Pain and Oral Medicine

Seo Eun Park1, Ji Rak Kim2, Jung Hwan Jo3, Ji Woon Park1

1Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea
2Department of Dentistry and Oral Medicine, School of Medicine, Catholic University of Daegu, Daegu, Korea
3Department of Oral Medicine, Seoul National University Dental Hospital, Seoul, Korea
Correspondence to: Ji Woon Park
Orofacial Pain Clinic, Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, 103 Daehak-ro, Jongnogu, Seoul 03080, Korea
Tel: +82-2-2072-4912
Fax: +82-2-744-9135
Received May 31, 2018; Revised June 20, 2018; Accepted June 22, 2018.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: The aim of this study was to evaluate the possibility of utilizing blood tests for the diagnosis of temporomandibular disorders (TMDs) by investigating the hematologic characteristics of TMD patients according to the main source and level of TMD pain and analyzing their interrelationship.
Methods: Clinical examination following the research diagnostic criteria for TMD and hematological and psychological evaluations were conducted in 357 TMD patients. Patients were divided into groups according to the main source of pain (myogenous, arthrogenous, and combined pain) and the degree of pain according to the graded chronic pain scale (GCPS). Hematological differences among the groups were statistically analyzed.
Results: The C-reactive protein (CRP) level was significantly higher in the arthrogenous pain group compared to the combined pain group (p=0.032). There was no significant difference according to the GCPS classification. There were significant correlations between some of the TMD pain indices and the hematologic indices, and also between the psychological indices and the hematologic indices.
Conclusions: This study suggests the possibility of applying blood tests to the diagnosis, treatment and prevention of TMD. Further research should be conducted focusing on the role of CRP in TMD pain with more refined methodology and a longitudinal study design.
Keywords : C-reactive protein; Hematologic tests; Pain; Temporomandibular disorders

March 2019, 44 (1)