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Sjögren's Syndrome: an Update on Diagnostic, Clinical, and Basic Aspects for Oral Medicine Specialists
J Oral Med Pain 2018;43:99-111
Published online December 30, 2018;
© 2018 Korean Academy of Orofacial Pain and Oral Medicine

Kyung-Eun Lee

Department of Oral Medicine, School of Dentistry, Institute of Oral Bioscience, Chonbuk National University, Jeonju, Korea
Correspondence to: Kyung-Eun Lee Department of Oral Medicine, School of Dentistry, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju 54896, Korea
Tel: +82-63-250-2060
Fax: +82-63-250-2058
Received November 30, 2018; Revised December 24, 2018; Accepted December 24, 2018.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sjögren’s syndrome (SjS) is a common autoimmune disorder characterized by lymphocytic infiltration in the salivary and lacrimal glands, resulting in severe dry mouth or eyes. As a result, most of SjS patients suffer from oral dryness and can visit the department of oral medicine with or without diagnosis of SjS. Therefore, oral medicine specialists should know clues, which may indicate the diagnosis of SjS from the clinical and laboratory investigations. By the recent SjS criteria, SjS can be diagnosed by focus score, ocular staining, Schirmer’s test, unstimulated whole saliva flow rate, and anti-SSA/Ro antibodies. The aim of this article is to review the diagnostic criteria, clinical investigation, and basic aspect related to SjS and to make oral medicine specialists play an important role in the detection of emerging SjS.
Keywords : Biopsy; Oral medicine; Sjögren’s syndrome; SSA antibodies; Staining and Labeling; Xerostomia

March 2019, 44 (1)