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Metal Ion Released from Old Prostheses May Affect Oral Lesions:A Pilot Study
J Oral Med Pain 2018;43:131-135
Published online December 30, 2018;  https://doi.org/10.14476/jomp.2018.43.4.131
© 2018 Korean Academy of Orofacial Pain and Oral Medicine

Hye-Min Ju1,2, Ji-Su Kim2, Yong-Woo Ahn2, Soo-Min Ok2, Sung-Hee Jeong2

1Department of Oral Medicine, Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Korea 2Department of Oral Medicine, Dental Research Institute, Pusan National University School of Dentistry, Yangsan, Korea
Correspondence to: Sung-Hee Jeong Department of Oral Medicine, Dental Research Institute, Pusan National University School of Dentistry, 49 Busandaehak-ro, Mulgeum-eup, Yangsan 50612, Korea
Tel: +82-55-360-5242
Fax: +82-55-360-5238
E-mail: drcookie@pusan.ac.kr
Received November 7, 2018; Revised December 15, 2018; Accepted December 28, 2018.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Purpose: To investigate the correlation between the amount of salivary metal ions released from fixed prostheses and the period of restoration insertion, and to evaluate the correlation between the type and amount of metal ions in saliva and oral lesions (OL).
Methods: Based on the oldest prosthesis, we divided patients into two groups: more than 5 years (n=19) and less than 5 years (n=10). Patients were also divided into two groups by another criteria: the one with the presence (n=15), and the one with absence (n=14) of OL, and the amounts of metal ions were examined. Metal ions—gold (Au), copper, cobalt (Co), chromium (Cr), nickel, zinc, aluminum, palladium (Pd), tin, and platinum (Pt)—were measured using laser ablation microprobe inductively coupled plasma mass spectrometry.
Results: Significantly higher quantities of Co, Pt, and Pd ions were released in patients with fixed prosthesis of more than 5 years (p<0.05). Measurement of the average amount of salivary metal ions was performed on patients with and without OL - Significantly higher amounts of Cr, Pd and Au ions were released in patients with OL (p<0.05).
Conclusions: Old prostheses (≥5 years) released metal ions, and among them were Co, Pt and Pd ions more than others. Patients with OL showed significantly higher levels of ion release, especially Cr, Pd and Au. There was a positive correlation between the amount of a certain kind of released metal ions, especially Pd, and the development of OL. Salivary Pd ion released from old prostheses could affect the pathogenesis of OL; therefore, long-term follow-up is important.
Keywords : Metals; Old prosthesis; Oral lesion; Saliva


December 2018, 43 (4)