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Evaluation of Clinically Effective Doses of Triamcinolone Acetonide for Intralesional Injection in Oral Lichen Planus
J Oral Med Pain 2019;44:1-10
Published online March 30, 2019;  https://doi.org/10.14476/jomp.2019.44.1.1
© 2019 Korean Academy of Orofacial Pain and Oral Medicine

Su-Hyeon Park1, Hae-Ohk Lee1, Hye-Min Ju1, Ji-Yeon Lee1, Hye-Mi Jeon2, Soo-Min Ok1, Yong-Woo Ahn1, Sung-Hee Jeong1

1Department of Oral Medicine, Dental Research Institute, Institute of Translational Dental Sciences, School of Dentistry, Pusan National University, Yangsan, Korea, 2Department of Oral Medicine, Pusan National University Hospital, Busan, Korea
Correspondence to: Sung-Hee Jeong
Department of Oral Medicine, Dental Research Institute, Institute of Translational Dental Sciences, School of Dentistry, Pusan National University, 49 Busandaehak-ro, Mulgeum-eup, Yangsan 50612, Korea, Tel: +82-55-350-5242 Fax: +82-55-360-5234, E-mail: drcookie@pusan.ac.kr, https://orcid.org/0000-0002-6296-4775
Received October 19, 2018; Revised March 4, 2019; Accepted March 7, 2019.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Purpose: The aim of this study was to evaluate the optimal doses of intralesional triamcinolone acetonide (TA) in the treatment of oral lichen planus (OLP).
Methods: A randomized clinical trial was performed. Sixty-two lesions of OLP were received 12 mg (group A) or 20 mg (group B) of TA intralesionally weekly for 2 weeks. Subjective symptoms, lesion size, favorable conversion of clinical subtypes, and clinical response were evaluated at weeks 0, 1, 2, and 4.
Results: After two consecutive injections of TA, group B showed significant reduction in burning sensation and reticular area (p<0.01). Favorable conversion and complete response were greater in group B. Mild oral candidiasis was developed in group B (10.7%).
Conclusions: A 20-mg injection of TA was much more effective compared with 12-mg injection of TA in the treatment of OLP.
Keywords : Intralesional injections; Oral lichen planus; Triamcinolone acetonide


June 2019, 44 (2)