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Peripheral Neuropathy in the Orofacial Region after Third Molar Extraction as an Initial Manifestation of Anemia: Two Case Reports
J Oral Med Pain 2019;44:40-44
Published online March 30, 2019;
© 2019 Korean Academy of Orofacial Pain and Oral Medicine

Hye-Kyoung Kim, Mee-Eun Kim

Department of Oral Medicine, Dankook University College of Dentistry, Cheonan, Korea
Correspondence to: Mee-Eun Kim
Department of Oral Medicine, Dankook University College of Dentistry, 119 Dandaero, Dongnam-gu, Cheonan 31116, Korea, Tel: +82-41-550-1915 Fax: +82-41-434-7951, E-mail:,
Received February 28, 2019; Revised March 24, 2019; Accepted March 27, 2019.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Third molar extraction, one of the important surgical treatments commonly practiced in dentistry, presents various symptoms after surgery ranging from temporary or mild symptoms to permanent or severe complications. However, oral burning pain, dysesthesia, parageusia, dry mouth, headache and pain in multiple teeth are not the common symptoms that patients often complain after dental extraction. Here, the authors report two cases who presented acute neuropathic symptoms mentioned above in the orofacial regions following third molar extraction. At the initial examination, the healing of the tooth sockets of two patients was normal. One patient was diagnosed as megaloblastic anemia associated with Vitamin B12 deficiency and was referred to the Department of Hematology for assessing the underlying etiology of anemia. The laboratory test for the other patient revealed microcytic anemia related to iron deficiency. The patient with iron deficiency anemia was successfully treated with iron supplement. These two cases suggest that anemia, as an underlying systemic disease, may be a rare etiology explaining acute onset of peripheral neuropathy in the orofacial regions after third molar extraction and should be considered in the assessment of patients who report neuropathic symptoms after dental extraction.
Keywords : Anemia; Metabolic neuropathies; Peripheral neuropathy; Tooth extraction

June 2019, 44 (2)