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Oral Manifestation of Paraneoplastic Pemphigus
J Oral Med Pain 2019;44:118-122
Published online September 30, 2019;  https://doi.org/10.14476/jomp.2019.44.3.118
© 2019 Korean Academy of Orofacial Pain and Oral Medicine

Seurin Kim, In Hee Park, YounJung Park, Jeong-Seung Kwon, Jong-hoon Choi, Hyung-Joon Ahn

Department of Orofacial Pain and Oral Medicine, Dental Hospital of Yonsei University College of Dentistry, Seoul, Korea
Correspondence to: Hyung-Joon Ahn
Department of Orofacial Pain and Oral Medicine, Dental Hospital of Yonsei University College of Dentistry, 50-1 Yonseiro, Seodaemun-gu, Seoul 03722, Korea
Tel: +82-2-2228-3113 Fax: +82-2-393-5673 E-mail: HJAHN@yuhs.ac https://orcid.org/0000-0001-9669-9781
Received June 14, 2019; Revised July 9, 2019; Accepted July 9, 2019.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Paraneoplastic pemphigus (PNP) is a rare and often fatal autoimmune blistering disease accompanied by both benign and malignant neoplasms. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by PNP patients. Oral ulcers are initial lesions in various autoimmune diseases like pemphigus, bullous pemphigoid, erythema multiforme, graft-versus-host, lichen planus, it does not improved despite of high-dose steroid therapy. We report a-35-year-old female who presented oral ulceration, lip crust and skin lesions. By doing several examinations, such as enzyme-linked immunosorbent assay, incisional biopsy with indirect immunofluorescence, she was diagnosed PNP with non-Hodgkin’s lymphoma on pancreas.
Keywords : Enzyme-linked immunosorbent assay; Fluorescent antibody technique, indirect; Oral ulcer; Pemphigus